Выбор тактики ведения беременных с преэклампсией, ассоциированной с тромбофилией

Selecting management of pregnant women with pre-eclampsia associated with thrombophilia

Лоскутова Т.А.

08.09.2015 6793

№ 1 (1)

Цитировать:

Лоскутова Т.А. Выбор тактики ведения беременных с преэклампсией, ассоциированной с тромбофилией // Universum: медицина и фармакология : электрон. научн. журн. 2013. № 1 (1). URL: https://7universum.com/ru/med/archive/item/321 (дата обращения: 05.12.2025).

Прочитать статью:

Keywords: preeclampsia, pregnancy, prognosis, complications, thrombophilia, gene polymorphism, risk group, obstetrics management

АННОТАЦИЯ

Проведена разработка способа прогнозирования акушерских и перинатальных осложнений у беременных с преэклампсией, ассоциированной с тромбофилией. Расчет вероятности развития осложнений при преэклампсии, ассоциированной с тромбофилией, позволяет выявить беременных группы высокого риска развития осложнений и определить возможный срок продолжения беременность. Родоразрешение показано при вероятности развития осложнений более 0,632 и/или при появлении признаков ухудшения состояния плода или матери, после профилактики респираторного дистресc-синдрома плода.

ABSTRACT

А method of forecasting obstetric and perinatal complications in pregnant women with pre-eclampsia associated with thrombophilia was developed. The calculation of the probability of complications in pre-eclampsia, associated with thrombophilia, can detect pregnant women with high risk of complications and to determine the possible term of pregnancy prolongation. Delivery is indicated if the risk of complications is over 0,632 and/or when the signs of the aggravation of the fetus or the mother are registered and after the prevention activities of fetus respiratory distress syndrome.

Список литературы:

1.   Про затвердження клінічних протоколів з акушерської та гінекологічної допомоги: Наказ від 31.12.2004 р. / Міністерство охорони здоров’я України. — К., 2004. — № 676.
2.   Турчин В.Н. Теория вероятностей и математическая статистика. Основные понятия, примеры и задачи. / В.Н. Турчин. — Дн-ск, ИМА-ПРЕСС, 2012. — 576 с.
3.   Aggressive or expectant management for patients with severe pre-eclampsia between 28—34 weeks gestation: A randomized controlled trial. / H. Odendaal, R. Pattinson, R. Bam [et al.] // Obstet. Gynecol. — 1990 — Vol. 76 — P. 1070—1075.
4.   Aggressive versus expectant management of severe pre-eclampsia at 28 to 32 weeks gestation: a randomised controlled trial / B.Sibai, B. Mercer, E. Schiff [et al.] // Am J Obstet Gynecol. — 1994 — Vol. 171 — P. 818—822.
5.   Induction of labour versus expectant monitoring in women with pregnancy induced hypertension or mild preeclampsia at term: the HYPITAT trial / C.M. Koopmans, D. Bijlenga3, J.G. Aarnoudse [et al.] // BMC Pregnancy and childbirth / [Электронный ресурс] — Режим доступа: http://www.biomedcentral.com/1471-2393/7/14 (дата обращения 7.11.2013).
6.   Intervention rates after elective induction of labor compared with a spontaneous onset; a matched cohort study. / N. Van Gemund, A. Hardeman, S.A. Scherjon [et al.] // Gynecol. Obstet. Invest. — 2003 — Vol. 56 — P. 133—138.
7.   Maslow A.S. Elective induction of labor as a risk factor for cesarean delivery among low-risk women at term / A.S. Maslow, A.L. Sweeny // Obstet Gynecol. — 2000 — Vol. 95 — P. 917—922.
8.   Maternal and perinatal outcome after expectant management of the HELLP syndrome compared with pre-eclampsia without HELLP syndrome / M.G. Pampus, H. Wolf, S.M. Westenberg [et al.]// Eur. J. Obstet. Gynaecol. Reprod. Biol. — 1998 — Vol. 76 — P. 31—36.
9.   Outcome after elective labor induction in nulliparous women: a matched control study / H. Cammu, G. Martens, G. Ruyssinck [et al.] // Am J Obstet Gynecol. — 2002 — Vol. 186 — P. 240—244.
10.   Redman C.W. Management of pre-eclampsia / C.W. Redman, J.M. Roberts // Lancet — 1993 — Vol. 341 — P. 1451—1454.
11.   Short- and long-term outcome of infants born after maternal (pre)-eclampsia, HELLP syndrome and thrombophilia: a retrospective, cohor tstudy./ J.M. Boomsma, R.A. Van Lingen, J. Van Eyck [et al.] // Eur. J. Obstet. Gynecol. Reprod. Biol. — 2010. — Vol. 153, № 1. — Р. 47—51.
12.   Sibai B.M. Diagnosis and management of gestational hypertension and preeclampsia. / B.M. Sibai // Obstet Gynecol. — 2003 — Vol. 102. — P. 181—192.
13.   What we have learned about peeclampsia. / B.M. Sibai, S. Caritis, J. Hauth / Semin Perinatol. — 2003 — Vol. 27 — P. 239—246.

References:

1. On approval of clinical protocols for obstetric and gynecological care: Order of 31.12.2004. Ministry of Health of Ukraine. Kiev, 2004. no. 676 (In Ukrainian).
2. Turchin V.N. Theory of Probability and Mathematical Statistics. Basic terms, examples and problems. Dnepropetrovsk, IMA-PRESS Publ., 2012. 576 p. (In Russian).
3. Odendaal H., Pattinson R., Bam R. Aggressive or expectant management for patients with severe pre-eclampsia between 28–34 weeks gestation: A randomized controlled trial. Obstet. Gynecol, 1990. vol. 76, pp. 1070-1075.
4. Sibai B., Mercer B., Schiff E. Aggressive versus expectant management of severe pre-eclampsia at 28 to 32 weeks gestation: a randomised controlled trial. Am J Obstet Gynecol, 1994. vol. 171, pp. 818-822.
5. Koopmans C.M., Bijlenga3 D., Aarnoudse J.G. Induction of labour versus expectant monitoring in women with preg nancy induced hypertension or mild preeclampsia at term: the HYPITAT trial. BMC Pregnancy and childbirth. Available at: http://www.biomedcentral.com/1471-2393/7/14 (accessed 7 November 2013).
6. Van Gemund N., Hardeman A., Scherjo S.A. Intervention rates after elective induction of labor compared with a spontaneous onset; a matched cohort study. Gynecol. Obstet. Invest, 2003. vol. 56, pp. 133-138.
7. Maslow A.S. Elective induction of labor as a risk factor for cesarean delivery among low-risk women at term. Obstet Gynecol, 2000. vol. 95, pp. 917-922.
8. Pampus M.G., Wolf H., Westenberg S.M. Maternal and perinatal outcome after expectant management of the HELLP syndrome compared with pre-eclampsia without HELLP syndrome. Eur. J. Obstet. Gynaecol. Reprod. Biol., 1998. vol. 76, pp. 31-36.
9. Cammu H., Martens G., Ruyssinck G. Outcome after elective labor induction in nulliparous women: a matched control study. Am J Obstet Gynecol, 2002. vol. 186, pp. 240-244.
10.  Redman C.W. Management of pre-eclampsia, Lancet Publ., 1993. vol. 341, pp. 1451-1454.
11.  Boomsma J.M., Van Lingen R.A., Van Eyck J. Short- and long-term outcome of infants born after maternal (pre)-eclampsia, HELLP syndrome and thrombophilia: a retrospective, cohor tstudy. Eur. J. Obstet. Gynecol. Reprod. Biol, 2010. vol. 153, no. 1, pp. 47-51.
12.  Sibai B.M. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol, 2003. vol. 102, pp. 181–192.
13.  Sibai B.M., Caritis S., Hauth J. What we have learned about peeclampsia, Semin Perinatol Publ., 2003. vol. 27, pp. 239-246.

Информация об авторах

Лоскутова Татьяна Александровна

канд.мед.наук, доцент кафедры акушерства и гинекологии ГУ Днепропетровская медицинская академия МОЗ Украины, Украина, г. Днепропетровск

Loskutova Tatyana Alexandrovna

PhD, assistant professor in obstetrics and gynecology department. State Institution «Dnepropetrovsk Medical Academy of Ministry of Health of Ukraine», Ukraine, Dnepropetrovsk