канд. мед. наук, доцент, Северо-Западный государственный медицинский университет им. И.И. Мечникова, 195067, Россия, г. Санкт-Петербург, пр. Пискаревский, д. 47
Определение нейротрофинов в сыворотке крови у детей больных детским цереберальным параличом
АННОТАЦИЯ
В статье представлены результаты комплексного клинико-лабораторного обследования 66 детей больных детским церебральным параличом (ДЦП). Выявлено, что уровень фактора роста нерва (NGF) и цилиарный нейротрофический фактор (CNTF) в сыворотке крови выше у детей больных ДЦП с синдромом локально обусловленной эпилепсией, нейротрофический фактор головного мозга (BDNF) не имеет статистически значимых отличий от данных контрольной группы.
ABSTRACT
The article presents results of complex clinic-laboratorial examination of 66 patients with infantile cerebral palsy (ICP). It is found that the level of nerve growth factor (NGF) and ciliary neurotrophic factor (CNTF) in blood serum is higher with ICP children with syndrome of localized associated epilepsy; brain-derived neurotrophic factor (BDNF) does not have statistically significant differences from data of control group.
Список литературы:
1. Петрухин А.С. Неврология детского возраста. М.: Медицина, 2004. — 784 с.
2. Davies A.M. The role of neurotrophins in the developing nervous system / A.M. Davies [et al.] // J. Neurobiol. — 1994. — V. 25, — № 11. —
P. 1134—1148.
3. Forgie A. In vivo survival requirement of a subset of nodose ganglion neurons for nerve growth factor / A. Forgie [et al.] // J. Neurosci. — 2000. — № 12. — P. 70—76.
4. Kulbatski I. Region-specific differentiation potential of adult rat spinal cord neural stem/precursors and their plasticity in response to in vitro manipulation / I. Kulbatski [et al.] // Neuropharmacology. — 2009. — № 2. — P. 40—43.
5. Leibinger M. Neuronal STAT3 activation is essential for CNTF- and inflammatory stimulation-induced CNS axon regeneration /M. Leibinger [et al.] // Cell Death Dis. — 2013. — № 11. — P. 10—18.
6. Liu Y. Ontogeny of brain-derived neurotrophic factor gene expression in the forebrain of prairie and montane voles / Y. Liu [et al.] // Dev Brain Res. — 2001. — Vol. 127, — № 1. — Р. 51—61.
7. Siegel S. Neurotrophic factor is required for motoneuron sprouting / S. Siegel [et al.] // Exp. Neurol. — 2000. — V. 166. — P. 205—212.
8. Wang N. Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition / N. Wang [et al.] // J. Neuropharmacology. — 2014. — Vol. 70, — № 4. — Р. 54—67.
References:
1. Petrukhin A.S. Neurology of childhood. Moscow, Meditsina Publ., 2004. 784 p. (In Russian).
2. Davies A.M. The role of neurotrophins in the developing nervous system. J. Neurobiol, 1994, vol. 25, no. 11, pp. 1134—1148.
3. Forgie A. In vivo survival requirement of a subset of nodose ganglion neurons for nerve growth factor. J. Neurosci., 2000, no. 12, pp. 70—76.
4. Kulbatski I. Region-specific differentiation potential of adult rat spinal cord neural stem/precursors and their plasticity in response to in vitro manipulation. Neuropharmacology, 2009, no. 2, pp. 40—43.
5. Leibinger M. Neuronal STAT3 activation is essential for CNTF- and inflammatory stimulation-induced CNS axon regeneration. Cell Death Dis., 2013, no. 11, pp. 10—18.
6. Liu Y. Ontogeny of brain-derived neurotrophic factor gene expression in the forebrain of prairie and montane voles. Dev Brain Res., 2001, vol. 127, no. 1, pp. 51—61.
7. Siegel S. Neurotrophic factor is required for motoneuron sprouting. Exp. Neurol., 2000, vol. 166, pp. 205—212.
8. Wang N. Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition. J. Neuropharmacology, 2014, vol. 70, no. 4, pp. 54—67.