Structural characteristics research of inclusion complex of disulfiram with hydroxypropyl-β-cyclodextrin

This article is available in Russian only.

Tyukova Viktoriya Kedik Stanislav Panov Aleksey Ogarkova Polina Nikolayeva Elena

13.12.2015 2182

No. 7-8 (19)

48. Technology of drug production

Цитировать:

Исследование структурных характеристик комплекса включения дисульфирама с гидроксипропил-β-циклодекстрином // Universum: медицина и фармакология : электрон. научн. журн. Тюкова В.С. [и др.]. 2015. № 7-8 (19). URL: https://7universum.com/en/med/archive/item/2551 (дата обращения: 29.05.2026).

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Keywords: hydroxypropyl-β-cyclodextrin, disulfiram, inclusion complex, complex structure, X-ray structural analysis, powder X-ray diffraction

АННОТАЦИЯ

В данной работе получен комплекс включения дисульфирама с гидроксипропил-β-циклодекстрином в виде порошка. Методом висячей капли во влажной камере получены кристаллы, пригодные для рентгеноструктурного анализа, в ходе которого установлено, что из насыщенного раствора комплекса выкристаллизовывается дисульфирам. Аморфная природа комплекса включения и гидроксипропил-β-циклодекстрина подтверждена методом порошковой рентгеновской дифракции. По отсутствию интенсивных пиков на дифрактограмме комплекса включения, характеризующих кристаллическую структуру дисульфирама, подтверждено образование комплекса включения.

ABSTRACT

The authors have obtained inclusion complex of disulfiram with hydroxypropyl-β-cyclodextrin in a powder form. By the hanging drop method in a humid chamber crystals suitable for X-ray structural analysis are obtained in which it is established that disulfiram crystallizes from a saturated solution of the complex. The amorphous nature of the inclusion complex and hydroxypropyl-β-cyclodextrin is confirmed by a powder X-ray diffraction method. According to the absence of intense peaks in the diffractogram of the inclusion complex characterizing the crystalline structure of disulfiram, the formation of the inclusion complex is confirmed.

Список литературы:

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References:

1. State Pharmacopoeia of the USSR. X. 1. 11th edition. Moscow, State Pharmacopoeia Committee Publ., 1987. 334 p. (In Russian).
2. Disulfiram (Disulfiramum). Internet-spravochnik lekarstv. [Online medication guide]. Available at: http://avitsena.com.ua/ru/spravochnik_lekarstv/d/disulfiram.html (accessed: 24 July 2015).
3. Astray G. A review on the use of cyclodextrins in foods. Food Hydrocolloids, 2009, vol. 23, pp. 1631—1640.
4. Chaudhary A. Enhancement of solubilization and bioavailability of poorly soluble drugs by physical and chemical modifications: A recent review. Journal of Advanced Pharmacy Education & Research, 2012, vol. 2 (1), pp. 32—67.
5. Del Valle E. M.M. Cyclodextrins and their uses: a review. Process Biochemistry, 2004, vol. 39, pp. 1033—1046.
6. Nagai N., Ito Y., Takeuchi N. Correlation between hyper-sensitivity to hydrogen peroxide and low defense against ca2_ influx in cataractogenic lens of ihara cataract rats. Biol. Pharm. Bull., 2011, vol. 34(7), pp. 1005—1010.
7. Nagai N., Ito Y., Takeuchi N. Effect of disulfiram eye drops on lipid peroxide formation via excessive nitric oxide in lenses of hereditary cataract icr/f rats. Biol. Pharm. Bull., 2008, vol. 31(5), pp. 981—985.
8. Nagai N., Ito Y., Takeuchi N. Pharmacokinetic and pharmacodynamic evaluation of the anti-cataract effect of eye drops containing disulfiram and low-substituted methylcellulose using icr/f rats as a hereditary cataract model. Pharm. Bull., 2012, vol. 35(2), pp. 239—245.
9. Nagai N., Takeda Maki, Ito Y., Takeuchi N., Kamei A. Delay in ICR/f Rat Lens Opacification by the Instillation of Eye Drops Containing Disulfiram and Hydroxypropyl-b-cyclodextrin Inclusion Complex. Biol. Pharm. Bull., 2007, vol. 30(8), pp. 1529—1534.

Информация об авторах

Tyukova Viktoriya

Post-graduate student of Lomonosov Moscow State University of Fine Chemical Technologies, Russia, Moscow

Kedik Stanislav

Professor, Doctor of Technical Sciences, Head of Biomedical and Pharmaceutical Engineering Chair, Lomonosov Moscow State University of Fine Chemical Technologies, Russia, Moscow

Panov Aleksey

Candidate of Chemical Sciences, Associate Professor of Biomedical and Pharmaceutical Engineering Chair, Lomonosov Moscow State University of Fine Chemical Technologies, Russia, Moscow

Ogarkova Polina

Student, Lomonosov Moscow State University of Fine Chemical Technologies, Russia, Moscow

Nikolayeva Elena

Student, Lomonosov Moscow State University of Fine Chemical Technologies, Russia, Moscow