Identification of neurotrophins in blood serum with children having infantile cerebral palsy

This article is available in Russian only.

Sokolova Maria

10.11.2015 3120

No. 9 (10)

11. Nervous diseases

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Соколова М.Г. Определение нейротрофинов в сыворотке крови у детей больных детским цереберальным параличом // Universum: медицина и фармакология : электрон. научн. журн. 2014. № 9 (10). URL: https://7universum.com/en/med/archive/item/1587 (дата обращения: 29.05.2026).

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Keywords: infantile cerebral palsy; brain-derived neurotrophic factor; nerve growth factor; ciliary neurotrophic factor; localized associated epilepsy; immunoenzyme method

АННОТАЦИЯ

В статье представлены результаты комплексного клинико-лабораторного обследования 66 детей больных детским церебральным параличом (ДЦП). Выявлено, что уровень фактора роста нерва (NGF) и цилиарный нейротрофический фактор (CNTF) в сыворотке крови выше у детей больных ДЦП с синдромом локально обусловленной эпилепсией, нейротрофический фактор головного мозга (BDNF) не имеет статистически значимых отличий от данных контрольной группы.

ABSTRACT

The article presents results of complex clinic-laboratorial examination of 66 patients with infantile cerebral palsy (ICP). It is found that the level of nerve growth factor (NGF) and ciliary neurotrophic factor (CNTF) in blood serum is higher with ICP children with syndrome of localized associated epilepsy; brain-derived neurotrophic factor (BDNF) does not have statistically significant differences from data of control group.

Список литературы:

1. Петрухин А.С. Неврология детского возраста. М.: Медицина, 2004. — 784 с.
2. Davies A.M. The role of neurotrophins in the developing nervous system / A.M. Davies [et al.] // J. Neurobiol. — 1994. — V. 25, — № 11. —
P. 1134—1148.
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5. Leibinger M. Neuronal STAT3 activation is essential for CNTF- and inflammatory stimulation-induced CNS axon regeneration /M. Leibinger [et al.] // Cell Death Dis. — 2013. — № 11. — P. 10—18.
6. Liu Y. Ontogeny of brain-derived neurotrophic factor gene expression in the forebrain of prairie and montane voles / Y. Liu [et al.] // Dev Brain Res. — 2001. — Vol. 127, — № 1. — Р. 51—61.
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8. Wang N. Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition / N. Wang [et al.] // J. Neuropharmacology. — 2014. — Vol. 70, — № 4. — Р. 54—67.

References:

1. Petrukhin A.S. Neurology of childhood. Moscow, Meditsina Publ., 2004. 784 p. (In Russian).
2. Davies A.M. The role of neurotrophins in the developing nervous system. J. Neurobiol, 1994, vol. 25, no. 11, pp. 1134—1148.
3. Forgie A. In vivo survival requirement of a subset of nodose ganglion neurons for nerve growth factor. J. Neurosci., 2000, no. 12, pp. 70—76.
4. Kulbatski I. Region-specific differentiation potential of adult rat spinal cord neural stem/precursors and their plasticity in response to in vitro manipulation. Neuropharmacology, 2009, no. 2, pp. 40—43.
5. Leibinger M. Neuronal STAT3 activation is essential for CNTF- and inflammatory stimulation-induced CNS axon regeneration. Cell Death Dis., 2013, no. 11, pp. 10—18.
6. Liu Y. Ontogeny of brain-derived neurotrophic factor gene expression in the forebrain of prairie and montane voles. Dev Brain Res., 2001, vol. 127, no. 1, pp. 51—61.
7. Siegel S. Neurotrophic factor is required for motoneuron sprouting. Exp. Neurol., 2000, vol. 166, pp. 205—212.
8. Wang N. Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition. J. Neuropharmacology, 2014, vol. 70, no. 4, pp. 54—67.

Информация об авторах

Sokolova Maria

Associate professor, candidate of Medical Science, North-West State Medical University named after I.I. Mechnikov, 195067, Russia, Saint-Petersburg, av. Piskarevsky, 47