Некоторые свойства рекомбинантных иерсиний с плазмидами pFra и pCad бактерий чумы // Universum: химия и биология : электрон. научн. журн. Трухачев А.Л. [и др.]. 2015. № 1-2 (11). URL: https://7universum.com/en/nature/archive/item/1912 (дата обращения: 29.05.2026).
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Keywords: Yersinia pestis, Yersinia, exchange of plasmids, pathogenic effects, phagocytosis, natural locus of plague, PCR-analysis
АННОТАЦИЯ
Обсуждается реальность межвидовых обменов плазмидами у иерсиний, персистирующих в природных очагах чумы. Показано влияние плазмид чумного микроба на вирулентность, антифагоцитарную активность и иммуногенность возбудителей псевдотуберкулёза и кишечного иерсиниоза. Предложены праймеры для монолокусной видоспецифической ПЦР, высокоэффективные для детекции и идентификации плазмидных рекомбинантов иерсиний в культурах и при исследовании биологического материала от инфицированных носителей.
ABSTRACT
The reality of interspecies exchange of plasmids in Yersinia persistent in natural locus of plague is discussed. The influence of plasmid plague bacterium on virulence, antiphagocytic activity and immunogenicity of pseudotuberculosis activators and intestinal yersiniosis is shown. Primers for monolocus species-specific PCR, high-efficiency for the detection and identification of recombinant plasmid of Yersinia in cultures and in the study of biological material from infected agents are offered.
Head of Plague microbiology and other yersiniosis laboratory, Candidate of Medical Science, Rostov-on-Don Antiplague Institute of Rospotrebnadzor, Rostov-on-Don, Russia
Research scientist of Plague microbiology and other yersiniosis laboratory, Rostov-on-Don Antiplague Institute of Rospotrebnadzor, Rostov-on-Don, Russia
Research scientist of Plague microbiology and other yersiniosis laboratory, Rostov-on-Don Antiplague Institute of Rospotrebnadzor, Rostov-on-Don, Russia
Doctor of Medical Science, Professor, Leading research scientist of Plague microbiology and other yersiniosis laboratory, Rostov-on-Don Antiplague Institute of Rospotrebnadzor, Rostov-on-Don, Russia
Research Scientist of Plague Microbiology and Other Yersina Laboratory, FGHI “Rostov-on-Don antiplague Institute of Russian Federal Consumer Rights Protection and Human Health Control Service”, Russia, Rostov-on-Don
ISSN 2311-5459. Article metadata is hosted on the eLIBRARY.RU platform. Publisher — LLC «MCNO» Editor-in-Chief - Maxim V. Larionov.
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