The mechanisms of the omeprazole-induced diarrhea in rats

This article is available in Russian only.

Beregovaya Tatyana Pilipenko Sergey Tolstanova Anna Chervinskaya Tatyana Dovbinchuk Taisa Sherepitko Dmitry

03.08.2014 2578

No. 8 (8)

21. Biochemistry

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Механизмы омепразол-индуцированной диареи крыс // Universum: химия и биология : электрон. научн. журн. Береговая Т.В. [и др.]. 2014. № 8 (8). URL: https://7universum.com/en/nature/archive/item/1512 (дата обращения: 29.05.2026).

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Keywords: colon, water and electrolyte transport, colonic epithelium, omeprazole, hypergastrinemia, Na+, К+, Cl-, CFTR

АННОТАЦИЯ

Исследование механизмов омепразол-индуцированной диареи проводилось методом перфузии изолированного участка ободочной кишки у крыс in vivo. Определялись суммарные потоки воды и электролитов через эпителий ободочной кишки, а также уровень экспрессии протеина CFTR каналов в эпителии ободочной кишки после 28-суточного введения омепразола. Показано, что введение омепразола вызывает снижение уровня всасывания воды и Na⁺, повышение уровня всасывания К⁺ и Cl^- и увеличение уровня экспрессии CFTR каналов в эпителии ободочной кишки гипергастринемических крыс.

ABSTRACT

The mechanisms of omeprazole-induced diarrhea were investigated by using of isolated colonic loop perfusing technique in vivo. The net water and electrolyte absorption as well as level of CFTR protein expression were determinated in the colonic epithelium after 28-days of omeprazole administration. It was shown that omeprazole treatment induced the decreasing of the net water and Na⁺ absorption and increasing of the net K⁺ and Cl^- absorption. The level of CFTR protein expression was also increased in the colonic epithelium of hypergastrinemic rats.

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Информация об авторах

Beregovaya Tatyana

Doctor of Biology, professor, head of the research laboratory of “Pharmacology and experimental pathology”, Educational research center “Institute of Biology”, Kyiv National University named after Taras Shevchenko, Ukraine, Kyiv

Pilipenko Sergey

Candidate of Biology, doctoral candidate, Research laboratory of “Pharmacology and experimental pathology”, Educational research center “Institute of Biology”, Kyiv National University named after Taras Shevchenko, Ukraine, Kyiv

Tolstanova Anna

Doctor of Biology, Associate Professor, Department of Biochemistry, Kyiv National University named after Taras Shevchenko, Ukraine, Kyiv

Chervinskaya Tatyana

Candidate of Biology, leading engineer, Research laboratory of “Pharmacology and experimental pathology”, Educational research center “Institute of Biology”, Kyiv National University named after Taras Shevchenko, Ukraine, Kyiv

Dovbinchuk Taisa

Engineer, Research laboratory of “Pharmacology and experimental pathology”, Educational research center “Institute of Biology”, Kyiv National University named after Taras Shevchenko, Ukraine, Kyiv

Sherepitko Dmitry